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Thirteen is fired but rehired after making a real emotional connection with a patient. However, Thirteen continues on her downward spiral. Thirteen is also forced to become a guinea pig for whatever drugs a hostile patient receives in one of the episodes. In "After Hours", a then-unknown woman arrives at Thirteen's apartment with a serious wound in her abdomen. She is revealed to be a cellmate of Thirteen's from prison and makes Thirteen promise that Thirteen will not take her to a hospital, as she will be arrested and taken back to prison.
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House agrees and orders that she be put in a hyperbaric chamber. The team take a case about a man who collapses and says he can't move his leg. Taub thinks that the canned food points to heavy metal poisoning, but Chase thinks he's inhaled a toxin. Thirteen points out that the treatment for both is chelation.
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She's surprised he didn't know after finding her in jail. House confirms he knows she pled guilty to excessive prescribing, but wants to know what she really did. Thirteen thanks him for not telling the team about her jail time, but he says he did it so he could figure out why she went to jail without getting anyone's help. They come up to Thirteen's exit on the freeway, but she finds out that House plans to take her to the spud gun tournament.
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House and Thirteen always shared a wild-spirit bond, and it was so refreshing for him to make a selfless act that he didn’t immediately shove in the recipient’s face. To me, that’s one of the few real gestures of genuine care for another person (on an emotional level) we’ve seen from him in a while. After the case (surprise!) gets solved, House spotted Thirteen happy and beaming with her new girlfriend, with whom she had planned to move to Greece before House had pulled her back in. Upon seeing this, House fired Thirteen, knowing that if he hadn’t, her guilt would always make her return. She would always resent herself for wasting her talents for the chance to be happy — unless he gave her no choice. Stress is one of the major health issues that people who engage in busy lifestyles always have to cope with so you must take the necessary precautions needed to ensure an incredible health status.
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However, Thirteen doesn't think it is illegal drugs because her kidneys and heart seem to be fine. Chase thinks it might just be the hepatitis, but Thirteen reminds him if that were the issue, her whole body would be swollen, not just her left arm. Chase wants to do an environmental scan of the crack den, but Thirteen tells him he's an idiot to even consider it and points out her symptoms have to be related to the stab wound. She finally comes up with an idea - the stab wound used up all her clotting factors, and she started bleeding elsewhere. If that's the case, she could start bleeding elsewhere at any time.
While House's team is trying to find out what is wrong with the patient over the phone with House, House tells them not to rule out the husband. Thirteen tries to get House's attention, but he's ignoring her. Finally, Thirteen pipes up and everyone wonders who it is. Thirteen realizes House has tricked her into speaking up, but as the rest of the team wonder about where she's been, Thirteen reminds them that there are reasons other than infertility why people can't have kids. Thirteen says that the hospital is now crawling with bureaucrats.
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Its venom can cause seizures and heart problems. Thirteen tells them she had asthma as a child and it started acting up again when she moved to her latest apartment. House number 13 rewards people who stay focused on their dreams and do businesses that they love and appreciate.
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House thought so highly of Thirteen that he took a huge risk to hire her. Thirteen arrives and finds the patient's wife outside his room. However, she doesn't want to see him unless she and their sons mean more to him than other people do. Thirteen then goes to see Benjamin to ask about the kidney. She goes to leave, but Benjamin says he will give her the other kidney.
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Taub assists as Chase guides a small tube through a small incision in the patient's abdomen. The CT showed a calcification near the superior pyramid of the left kidney. She says she's merely trying to live life to the fullest. As Foreman and the team go through the case file, Thirteen laments that her private life is on display, but also thinks it's just dehydration from drugs. Foreman asks if Thirteen was also taking drugs.
Chase has figured out the patient used to be a police officer. Thirteen wonders why she was never told, and the woman tells her you don't tell people you were with the police if you're trying to survive in prison. She tells Thirteen that she killed a 19 year old. The team tells the assistant that Dr. Richardson's new symptoms are the result of high blood sugar, but the assistant doesn't think he's capable of doing surgery.
The patient then says that he'll trade House for the drugs. House realizes that he's going to give Thirteen the drug once again and tells the patient that he'll inject the drug in himself because more drugs would kill Thirteen. The patient doesn't care, noting that since Thirteen has taken everything that he's taken, any bad reactions she has to it would more accurately reflect what would happen to him. Thirteen tells House that she'll either die from the drug or the patient will shoot her, so she'll die either way.
However, Foreman convinced House they had done so while continuing to carry on their relationship. However, in Wilson's Heart, Thirteen is unable to deal with the prospect of a dying Amber. House tells her to deal with her fear or lose her job, so Thirteen tests herself during the episode.
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